Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity

Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity

Abstract Targeting important oncogenic kinases that contribute to hallmarks of cancer has revolutionized cancer therapy. Ten 1,4-naphthoquinone derivatives linked to 1,2,3-triazole (4a-4j) were designed and synthesized as kinase inhibitors especially aimed at blocking CDK2, a validated and important...

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Main Authors: Pegah Mardaneh, Somayeh Pirhadi, Maryam Mohabbati, Mehdi Khoshneviszadeh, Zahra Rezaei, Luciano Saso, Najmeh Edraki, Omidreza Firuzi
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
1,4-Naphthoquinone derivatives
Targeted therapy
CDK2 inhibitor
Antitumoral agents
Drug design
Online Access:https://doi.org/10.1038/s41598-025-87483-w
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https://doi.org/10.1038/s41598-025-87483-w

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