Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice
The timing of food intake is a novel dietary component that impacts health. Time-restricted feeding (TRF), a form of intermittent fasting, manipulates food timing. The timing of eating may be an important factor to consider during critical periods, such as pregnancy. Nutrition during pregnancy, too,...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2023/6666613 |
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| _version_ | 1832546608466624512 |
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| author | Molly C. Mulcahy Noura El Habbal Detrick Snyder JeAnna R. Redd Haijing Sun Brigid E. Gregg Dave Bridges |
| author_facet | Molly C. Mulcahy Noura El Habbal Detrick Snyder JeAnna R. Redd Haijing Sun Brigid E. Gregg Dave Bridges |
| author_sort | Molly C. Mulcahy |
| collection | DOAJ |
| description | The timing of food intake is a novel dietary component that impacts health. Time-restricted feeding (TRF), a form of intermittent fasting, manipulates food timing. The timing of eating may be an important factor to consider during critical periods, such as pregnancy. Nutrition during pregnancy, too, can have a lasting impact on offspring health. The timing of food intake has not been thoroughly investigated in models of pregnancy, despite evidence that interest in the practice exists. Therefore, using a mouse model, we tested body composition and glycemic health of gestational early TRF (eTRF) in male and female offspring from weaning to adulthood on a chow diet and after a high-fat, high-sucrose (HFHS) diet challenge. Body composition was similar between groups in both sexes from weaning to adulthood, with minor increases in food intake in eTRF females and slightly improved glucose tolerance in males while on a chow diet. However, after 10 weeks of HFHS, male eTRF offspring developed glucose intolerance. Further studies should assess the susceptibility of males, and apparent resilience of females, to gestational eTRF and assess mechanisms underlying these changes in adult males. |
| format | Article |
| id | doaj-art-852316f3b67f4a9d98e6946e0e2396e4 |
| institution | Kabale University |
| issn | 2090-0716 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-852316f3b67f4a9d98e6946e0e2396e42025-02-03T06:47:42ZengWileyJournal of Obesity2090-07162023-01-01202310.1155/2023/6666613Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male MiceMolly C. Mulcahy0Noura El Habbal1Detrick Snyder2JeAnna R. Redd3Haijing Sun4Brigid E. Gregg5Dave Bridges6University of Michigan School of Public HealthUniversity of Michigan School of Public HealthUniversity of Michigan School of Public HealthUniversity of Michigan School of Public HealthMichigan MedicineUniversity of Michigan School of Public HealthUniversity of Michigan School of Public HealthThe timing of food intake is a novel dietary component that impacts health. Time-restricted feeding (TRF), a form of intermittent fasting, manipulates food timing. The timing of eating may be an important factor to consider during critical periods, such as pregnancy. Nutrition during pregnancy, too, can have a lasting impact on offspring health. The timing of food intake has not been thoroughly investigated in models of pregnancy, despite evidence that interest in the practice exists. Therefore, using a mouse model, we tested body composition and glycemic health of gestational early TRF (eTRF) in male and female offspring from weaning to adulthood on a chow diet and after a high-fat, high-sucrose (HFHS) diet challenge. Body composition was similar between groups in both sexes from weaning to adulthood, with minor increases in food intake in eTRF females and slightly improved glucose tolerance in males while on a chow diet. However, after 10 weeks of HFHS, male eTRF offspring developed glucose intolerance. Further studies should assess the susceptibility of males, and apparent resilience of females, to gestational eTRF and assess mechanisms underlying these changes in adult males.http://dx.doi.org/10.1155/2023/6666613 |
| spellingShingle | Molly C. Mulcahy Noura El Habbal Detrick Snyder JeAnna R. Redd Haijing Sun Brigid E. Gregg Dave Bridges Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice Journal of Obesity |
| title | Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice |
| title_full | Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice |
| title_fullStr | Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice |
| title_full_unstemmed | Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice |
| title_short | Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice |
| title_sort | gestational early time restricted feeding results in sex specific glucose intolerance in adult male mice |
| url | http://dx.doi.org/10.1155/2023/6666613 |
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