NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria

ABSTRACT The NLRP11 protein is only expressed in primates and participates in the activation of the canonical NLRP3 and non-canonical NLRP3 inflammasome activation after infection with gram-negative bacteria. Here, we generated a series of defined NLRP11 deletion mutants to further analyze the role...

Full description

Saved in:
Bibliographic Details
Main Authors: Mateusz Szczerba, Akshaya Ganesh, María Luisa Gil-Marqués, Volker Briken, Marcia B. Goldberg
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
mycobacteria
innate immunity
macrophages
inflammasomes
NLRP11
NLRP3
Online Access:https://journals.asm.org/doi/10.1128/mbio.00818-25
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.asm.org/doi/10.1128/mbio.00818-25

Similar Items