A phase II single-arm study of combination pembrolizumab and olaparib in the treatment of patients with advanced biliary tract cancer

A phase II single-arm study of combination pembrolizumab and olaparib in the treatment of patients with advanced biliary tract cancer

Abstract Effective second-line treatment for advanced biliary tract cancer (BTC) remains an unmet need. BTC often presents with homologous recombination repair (HRR) pathway deficiencies and IDH1/IDH2 mutations which suggest responsiveness to Poly (ADP-ribose) polymerase inhibitors. Thirteen patient...

Full description

Saved in:
Bibliographic Details
Main Authors: Narayanan Sadagopan, Hongkun Wang, Chao Yin, Benjamin Adam Weinberg, Marcus Smith Noel, Reetu Mukherji, Xue Geng, John Lindsay Marshall, Aiwu Ruth He
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01009-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41698-025-01009-1

Similar Items