METTL3-mediated SNHG1 m6A modification promotes proliferation and migration through transcriptional regulation of WDR74 in osteosarcoma

METTL3-mediated SNHG1 m6A modification promotes proliferation and migration through transcriptional regulation of WDR74 in osteosarcoma

IntroductionAs the most prevalent internal RNA modification in eukaryotic transcripts, N6-methyladenosine (m6A) which is catalyzed by methyltransferase-like 3 (METTL3), is widely involved in cancerous diseases. However, the role of METTL3 and small nucleolar RNA host gene 1 (SNHG1) playing in osteos...

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Bibliographic Details
Main Authors: Guanzhen Qiu, Yuxin Bao, Yuanzhuang Zhang, Yeqiu Xu, Tianhua Qiao, Chenghao Li, Hanjie Zhai, Zhenjun Chen, Fu Ren, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
METTL3
N6-methyladenosine
SNHG1
WDR74
osteosarcoma
proliferation/metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1529657/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1529657/full

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