Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy
Genomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in counteracting oxidative DNA damage caused by re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/112 |
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| author | Anna Piscone Francesca Gorini Susanna Ambrosio Anna Noviello Giovanni Scala Barbara Majello Stefano Amente |
| author_facet | Anna Piscone Francesca Gorini Susanna Ambrosio Anna Noviello Giovanni Scala Barbara Majello Stefano Amente |
| author_sort | Anna Piscone |
| collection | DOAJ |
| description | Genomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in counteracting oxidative DNA damage caused by reactive oxygen species. Central to this pathway are enzymes like 8-oxoguanine glycosylase 1 (OGG1), which recognize and excise 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) lesions, thereby initiating a series of repair processes that restore DNA integrity. BER inhibitors have recently been identified as a promising approach in cancer therapy, increasing the sensitivity of cancer cells to radiotherapy and chemotherapy. By exploiting tumor-specific DNA repair dependencies and synthetic lethal interactions, these inhibitors could be used to selectively target cancer cells while sparing normal cells. This review provides a robust reference for scientific researchers, offering an updated perspective on small-molecule inhibitors targeting the 8-oxodG-BER pathway and highlighting their potential role in expanding cancer treatment strategies. |
| format | Article |
| id | doaj-art-84efc51c88f944c78a988d5d0d98395f |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-84efc51c88f944c78a988d5d0d98395f2025-01-24T13:26:43ZengMDPI AGCells2073-44092025-01-0114211210.3390/cells14020112Targeting the 8-oxodG Base Excision Repair Pathway for Cancer TherapyAnna Piscone0Francesca Gorini1Susanna Ambrosio2Anna Noviello3Giovanni Scala4Barbara Majello5Stefano Amente6Department of Molecular Medicine and Medical Biotechnologies, University of Naples ‘Federico II’, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples ‘Federico II’, 80131 Naples, ItalyDepartment of Biology, University of Naples ‘Federico II’, 80138 Naples, ItalyDepartment of Biology, University of Naples ‘Federico II’, 80138 Naples, ItalyDepartment of Biology, University of Naples ‘Federico II’, 80138 Naples, ItalyDepartment of Biology, University of Naples ‘Federico II’, 80138 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples ‘Federico II’, 80131 Naples, ItalyGenomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in counteracting oxidative DNA damage caused by reactive oxygen species. Central to this pathway are enzymes like 8-oxoguanine glycosylase 1 (OGG1), which recognize and excise 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) lesions, thereby initiating a series of repair processes that restore DNA integrity. BER inhibitors have recently been identified as a promising approach in cancer therapy, increasing the sensitivity of cancer cells to radiotherapy and chemotherapy. By exploiting tumor-specific DNA repair dependencies and synthetic lethal interactions, these inhibitors could be used to selectively target cancer cells while sparing normal cells. This review provides a robust reference for scientific researchers, offering an updated perspective on small-molecule inhibitors targeting the 8-oxodG-BER pathway and highlighting their potential role in expanding cancer treatment strategies.https://www.mdpi.com/2073-4409/14/2/112BER8-oxodGcancer therapy |
| spellingShingle | Anna Piscone Francesca Gorini Susanna Ambrosio Anna Noviello Giovanni Scala Barbara Majello Stefano Amente Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy Cells BER 8-oxodG cancer therapy |
| title | Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy |
| title_full | Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy |
| title_fullStr | Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy |
| title_full_unstemmed | Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy |
| title_short | Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy |
| title_sort | targeting the 8 oxodg base excision repair pathway for cancer therapy |
| topic | BER 8-oxodG cancer therapy |
| url | https://www.mdpi.com/2073-4409/14/2/112 |
| work_keys_str_mv | AT annapiscone targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy AT francescagorini targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy AT susannaambrosio targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy AT annanoviello targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy AT giovanniscala targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy AT barbaramajello targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy AT stefanoamente targetingthe8oxodgbaseexcisionrepairpathwayforcancertherapy |