Glutamate promotes CCL2 expression to recruit tumor-associated macrophages by restraining EZH2-mediated histone methylation in hepatocellular carcinoma

Glutamate promotes CCL2 expression to recruit tumor-associated macrophages by restraining EZH2-mediated histone methylation in hepatocellular carcinoma

Glutamate is well-known as metabolite for maintaining the energy and redox homeostasis in cancer, moreover it is also the primary excitatory neurotransmitter in the central nervous system. However, whether glutamatergic signaling can regulate hepatocellular carcinoma (HCC) progression and the specif...

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Bibliographic Details
Main Authors: Jing Chen, Hong-Wei Sun, Run-Zheng Wang, Yun-Fei Zhang, Wen-Jiao Li, Yong-Kui Wang, Hao Wang, Miao-Miao Jia, Qing-Xia Xu, Hao Zhuang, Ning Xue
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
CCL2
EZH2
glutamate
Hepatocellular carcinoma
macrophage
neurotransmitter
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2497172
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2497172

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