Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation

Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation

Abstract Parathyroid hormone (PTH) analogs with improved actions in vivo could lead to optimized treatments for bone and mineral ion diseases. Rapid clearance from the circulation and short dwell times on the PTH receptor limit the efficacies of conventional PTH peptides currently in medical use. He...

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Main Authors: Jakob Höppner, Hiroshi Noda, Anju Krishnan Anitha, Ross W. Cheloha, Thomas Dean, Michael Bruce, Daniel J. Brooks, Michael Mannstadt, Mary L. Bouxsein, Samuel H. Gellman, Ashok Khatri, Harald Jüppner, Thomas J. Gardella
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59665-7
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https://doi.org/10.1038/s41467-025-59665-7

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