Targeting ferroptosis: a promising approach for treating lung carcinoma
Abstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits. Ferroptosis, a d...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02308-z |
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| _version_ | 1832572012893044736 |
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| author | Ziyang Wu Yan Zhang Wendi Zhong Kunjian Wu Tian Zhong Tao Jiang |
| author_facet | Ziyang Wu Yan Zhang Wendi Zhong Kunjian Wu Tian Zhong Tao Jiang |
| author_sort | Ziyang Wu |
| collection | DOAJ |
| description | Abstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits. Ferroptosis, a distinct pattern of cell death marked by the buildup of iron-dependent lipid peroxides, has been shown to be a novel and potentially more effective treatment for lung carcinoma. However, the mechanism and regulatory network of ferroptosis are exceptionally complex, and many unanswered questions remain. In addition, research on ferroptosis in the diagnosis and treatment of lung cancer has been growing exponentially. Therefore, it is necessary to provide a thorough summary of the latest advancements in the field of ferroptosis. Here, we comprehensively analyze the mechanisms underlying the preconditions of ferroptosis, the defense system, and the associated molecular networks. The potential strategies of ferroptosis in the treatment of lung carcinoma are also highlighted. Targeting ferroptosis improves tumor cell drug resistance and enhances the effectiveness of targeted drugs and immunotherapies. These findings may shed fresh light on the diagnosis and management of lung carcinoma, as well as the development of drugs related to ferroptosis. |
| format | Article |
| id | doaj-art-849eb99e618c430da15f999a65a895d5 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-849eb99e618c430da15f999a65a895d52025-02-02T12:08:46ZengNature Publishing GroupCell Death Discovery2058-77162025-01-0111111210.1038/s41420-025-02308-zTargeting ferroptosis: a promising approach for treating lung carcinomaZiyang Wu0Yan Zhang1Wendi Zhong2Kunjian Wu3Tian Zhong4Tao Jiang5School of Life Sciences, Zhuhai College of Science and TechnologyDepartment of Thoracic Surgery, The First Hospital of Jilin UniversitySchool of Life Sciences, Zhuhai College of Science and TechnologySchool of Life Sciences, Zhuhai College of Science and TechnologyFaculty of Medicine, Macau University of Science and TechnologySchool of Life Sciences, Zhuhai College of Science and TechnologyAbstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits. Ferroptosis, a distinct pattern of cell death marked by the buildup of iron-dependent lipid peroxides, has been shown to be a novel and potentially more effective treatment for lung carcinoma. However, the mechanism and regulatory network of ferroptosis are exceptionally complex, and many unanswered questions remain. In addition, research on ferroptosis in the diagnosis and treatment of lung cancer has been growing exponentially. Therefore, it is necessary to provide a thorough summary of the latest advancements in the field of ferroptosis. Here, we comprehensively analyze the mechanisms underlying the preconditions of ferroptosis, the defense system, and the associated molecular networks. The potential strategies of ferroptosis in the treatment of lung carcinoma are also highlighted. Targeting ferroptosis improves tumor cell drug resistance and enhances the effectiveness of targeted drugs and immunotherapies. These findings may shed fresh light on the diagnosis and management of lung carcinoma, as well as the development of drugs related to ferroptosis.https://doi.org/10.1038/s41420-025-02308-z |
| spellingShingle | Ziyang Wu Yan Zhang Wendi Zhong Kunjian Wu Tian Zhong Tao Jiang Targeting ferroptosis: a promising approach for treating lung carcinoma Cell Death Discovery |
| title | Targeting ferroptosis: a promising approach for treating lung carcinoma |
| title_full | Targeting ferroptosis: a promising approach for treating lung carcinoma |
| title_fullStr | Targeting ferroptosis: a promising approach for treating lung carcinoma |
| title_full_unstemmed | Targeting ferroptosis: a promising approach for treating lung carcinoma |
| title_short | Targeting ferroptosis: a promising approach for treating lung carcinoma |
| title_sort | targeting ferroptosis a promising approach for treating lung carcinoma |
| url | https://doi.org/10.1038/s41420-025-02308-z |
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