Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

Orexin signaling in the ventral tegmental area and substantia nigra promotes locomotion and reward processing, but it is not clear whether dopaminergic neurons directly mediate these effects. We show that dopaminergic neurons in these areas mainly express orexin receptor subtype 1 (Ox1R). In contras...

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Bibliographic Details
Main Authors: Xing Xiao, Gagik Yeghiazaryan, Fynn Eggersmann, Anna Lena Cremer, Heiko Backes, Peter Kloppenburg, Anne Christine Hausen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
orexin
dopamine
context-induced locomotion
Online Access:https://elifesciences.org/articles/91716
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