Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype

Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype

Abstract Conventional laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, in recent years, many rodent-based studies have been deemed irreproducible, raising questions about the suitability of mice as model organisms. Emerging...

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Main Authors: Solveig Runge, Silvia von Zedtwitz, Alexander M. Maucher, Philipp Bruno, Lisa Osbelt, Bei Zhao, Anne M. Gernand, Till R. Lesker, Katja Gräwe, Manuel Rogg, Christoph Schell, Melanie Boerries, Till Strowig, Geoffroy Andrieux, Benedikt Hild, Stephan P. Rosshart
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60554-2
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