Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient
Because of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. However, this prophylaxis is not universally effective and may contribute to the selection of emerging, resistant pathogens....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2015/745638 |
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| author | Kelly E. Schoeppler Martin R. Zamora Noelle M. Northcutt Gerard R. Barber Gayle O’Malley-Schroeder Dennis M. Lyu |
| author_facet | Kelly E. Schoeppler Martin R. Zamora Noelle M. Northcutt Gerard R. Barber Gayle O’Malley-Schroeder Dennis M. Lyu |
| author_sort | Kelly E. Schoeppler |
| collection | DOAJ |
| description | Because of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. However, this prophylaxis is not universally effective and may contribute to the selection of emerging, resistant pathogens. Here we present a rare case of invasive infection caused by Microascus trigonosporus species complex in a human, which developed during voriconazole prophylaxis in a lung transplant recipient. Nebulized liposomal amphotericin B was used in addition to systemic therapy in order to optimize antifungal drug exposure; this regimen appeared to reduce the patient’s fungal burden. Despite this apparent improvement, the patient’s pulmonary status progressively declined in the setting of multiple comorbidities, ultimately leading to respiratory failure and death. |
| format | Article |
| id | doaj-art-847b11fdcc6d42d68f301b23a3dd7df0 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-847b11fdcc6d42d68f301b23a3dd7df02025-02-03T06:07:22ZengWileyCase Reports in Transplantation2090-69432090-69512015-01-01201510.1155/2015/745638745638Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant RecipientKelly E. Schoeppler0Martin R. Zamora1Noelle M. Northcutt2Gerard R. Barber3Gayle O’Malley-Schroeder4Dennis M. Lyu5Department of Pharmacy, University of Colorado Hospital, Aurora, CO 80010, USADepartment of Pulmonary and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80010, USAHospitalist Medicine, Denver Health and Hospital, Denver, CO 80204, USADepartment of Pharmacy, University of Colorado Hospital, Aurora, CO 80010, USADepartment of Mycology, University of Colorado Anschutz Medical Campus, Aurora, CO 80010, USADepartment of Pulmonary and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80010, USABecause of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. However, this prophylaxis is not universally effective and may contribute to the selection of emerging, resistant pathogens. Here we present a rare case of invasive infection caused by Microascus trigonosporus species complex in a human, which developed during voriconazole prophylaxis in a lung transplant recipient. Nebulized liposomal amphotericin B was used in addition to systemic therapy in order to optimize antifungal drug exposure; this regimen appeared to reduce the patient’s fungal burden. Despite this apparent improvement, the patient’s pulmonary status progressively declined in the setting of multiple comorbidities, ultimately leading to respiratory failure and death.http://dx.doi.org/10.1155/2015/745638 |
| spellingShingle | Kelly E. Schoeppler Martin R. Zamora Noelle M. Northcutt Gerard R. Barber Gayle O’Malley-Schroeder Dennis M. Lyu Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient Case Reports in Transplantation |
| title | Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient |
| title_full | Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient |
| title_fullStr | Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient |
| title_full_unstemmed | Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient |
| title_short | Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient |
| title_sort | invasive microascus trigonosporus species complex pulmonary infection in a lung transplant recipient |
| url | http://dx.doi.org/10.1155/2015/745638 |
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