Humanized VHH-hFc Fusion Proteins Targeting the L-HN Fragment of Tetanus Toxin Provided Protection In Vivo

Humanized VHH-hFc Fusion Proteins Targeting the L-HN Fragment of Tetanus Toxin Provided Protection In Vivo

Background: Tetanus toxin, produced by <i>Clostridium tetani</i>, is the second deadliest known toxin. Antibodies capable of neutralizing tetanus toxin (TeNT) are vital for preventing and treating tetanus disease. Methods: Herein, we screened thirty-six single variable domains on a heavy...

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Bibliographic Details
Main Authors: Yating Li, Kexuan Cheng, Jiazheng Guo, Yujia Jiang, Qinglin Kang, Rong Wang, Peng Du, Chen Gao, Yunzhou Yu, Zhixin Yang, Wei Wang, Jiansheng Lu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antibodies
Subjects:
tetanus toxin
TL-HN
VHH
phage-display library
humanized VHH-hFc fusion protein
neutralization
Online Access:https://www.mdpi.com/2073-4468/14/2/48
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