Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease
Background. Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. T...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/8296203 |
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| author | Megan C. Bakeberg Maddeson Riley Michelle Byrnes Alexa Jefferson Souyma Ghosh Malcom K. Horne Sarah McGregor Rick Stell Sue Walters Tess Evans Katherine Roberts Frank L. Mastaglia Ryan S. Anderton |
| author_facet | Megan C. Bakeberg Maddeson Riley Michelle Byrnes Alexa Jefferson Souyma Ghosh Malcom K. Horne Sarah McGregor Rick Stell Sue Walters Tess Evans Katherine Roberts Frank L. Mastaglia Ryan S. Anderton |
| author_sort | Megan C. Bakeberg |
| collection | DOAJ |
| description | Background. Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP. Methods. The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores. Results. Serum ceruloplasmin was higher in females with PD (p<0.001) and associated with MDS-UPDRS III, Hoehn and Yahr, and ACE-R scores (p<0.05). When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains. Conclusions. Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD. |
| format | Article |
| id | doaj-art-84401d526c0f48cc86982d2a7cecdaa6 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-84401d526c0f48cc86982d2a7cecdaa62025-02-03T06:46:30ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/82962038296203Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s DiseaseMegan C. Bakeberg0Maddeson Riley1Michelle Byrnes2Alexa Jefferson3Souyma Ghosh4Malcom K. Horne5Sarah McGregor6Rick Stell7Sue Walters8Tess Evans9Katherine Roberts10Frank L. Mastaglia11Ryan S. Anderton12Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaInstitute for Health Research, University of Notre Dame Australia, Fremantle, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, Western Australia, AustraliaBackground. Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP. Methods. The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores. Results. Serum ceruloplasmin was higher in females with PD (p<0.001) and associated with MDS-UPDRS III, Hoehn and Yahr, and ACE-R scores (p<0.05). When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains. Conclusions. Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD.http://dx.doi.org/10.1155/2020/8296203 |
| spellingShingle | Megan C. Bakeberg Maddeson Riley Michelle Byrnes Alexa Jefferson Souyma Ghosh Malcom K. Horne Sarah McGregor Rick Stell Sue Walters Tess Evans Katherine Roberts Frank L. Mastaglia Ryan S. Anderton Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease Parkinson's Disease |
| title | Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease |
| title_full | Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease |
| title_fullStr | Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease |
| title_full_unstemmed | Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease |
| title_short | Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease |
| title_sort | elevated serum ceruloplasmin levels are associated with higher impulsivity in people with parkinson s disease |
| url | http://dx.doi.org/10.1155/2020/8296203 |
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