Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors

Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors

Abstract This work presents a rational synthesis of 14 innovative methyl salicylate based thiazole (MSBT) derivatives, designed as protein tyrosine phosphatase 1B (PTP1B) inhibitors with potent anticancer activity. Enzyme inhibition studies were performed for all compounds. In addition, molecular do...

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Main Authors: Dominika Kołodziej-Sobczak, Łukasz Sobczak, Wojciech Płaziński, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Klaudia Hołub, Barbara Zdzisińska, Karol Jaroch, Barbara Bojko, Krzysztof Z. Łączkowski
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Protein tyrosine phosphatase 1B
Enzyme inhibitor
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-88038-9
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https://doi.org/10.1038/s41598-025-88038-9

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