T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration
Last decade has witnessed increasing evidence which highlights the roles of immune cells in bone regeneration. Numerous immune cell types, including macrophages, T cells, and neutrophils are involved in fracture healing by orchestrating a series of events that modulate bone formation and remodeling....
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Orthopaedic Translation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X24001621 |
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| author | Haixing Wang Yashi Li Haoxin Li Xu Yan Zhaowei Jiang Lu Feng Wenhui Hu Yinuo Fan Sien Lin Gang Li |
| author_facet | Haixing Wang Yashi Li Haoxin Li Xu Yan Zhaowei Jiang Lu Feng Wenhui Hu Yinuo Fan Sien Lin Gang Li |
| author_sort | Haixing Wang |
| collection | DOAJ |
| description | Last decade has witnessed increasing evidence which highlights the roles of immune cells in bone regeneration. Numerous immune cell types, including macrophages, T cells, and neutrophils are involved in fracture healing by orchestrating a series of events that modulate bone formation and remodeling. In this review, the role of T cell immunity in fracture healing has been summarized, and the modulatory effects of T cell immunity in inflammation, bone formation and remodeling have been highlighted. The review also summarizes the specific roles of different T cell subsets, including CD4+ T cells, CD8+ T cells, regulatory T cells, T helper 17 cells, and γδ T cells in modulating fracture healing. The current therapeutics targeting T cell immunity to enhance fracture healing have also been reviewed, aiming to provide insights from a translational standpoint. Overall, this work discusses recent advances and challenges in the interdisciplinary research field of T cell related osteoimmunology and its implications in fracture healing. The translational potential of this article: Delayed unions or non-unions of bone fractures remain a challenge in clinical practice. Developing a deep understanding of the roles of immune cells, including T cells, in fracture healing will facilitate the advancement of novel therapeutics of fracture nonunion. This review summarizes the current understanding of different T cell subsets involved in various phases of fracture healing, providing insights for targeting T cells as an alternative strategy to enhance bone regeneration. |
| format | Article |
| id | doaj-art-83f837de60a94addace1336f0920137c |
| institution | Kabale University |
| issn | 2214-031X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj-art-83f837de60a94addace1336f0920137c2025-02-06T05:11:44ZengElsevierJournal of Orthopaedic Translation2214-031X2025-03-01518293T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regenerationHaixing Wang0Yashi Li1Haoxin Li2Xu Yan3Zhaowei Jiang4Lu Feng5Wenhui Hu6Yinuo Fan7Sien Lin8Gang Li9Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China; Department of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, ChinaOrthopaedic Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong Province, ChinaThe Third Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, ChinaDepartment of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Corresponding author. Department of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China.Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China; Department of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Corresponding author. Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, 518000, China.Last decade has witnessed increasing evidence which highlights the roles of immune cells in bone regeneration. Numerous immune cell types, including macrophages, T cells, and neutrophils are involved in fracture healing by orchestrating a series of events that modulate bone formation and remodeling. In this review, the role of T cell immunity in fracture healing has been summarized, and the modulatory effects of T cell immunity in inflammation, bone formation and remodeling have been highlighted. The review also summarizes the specific roles of different T cell subsets, including CD4+ T cells, CD8+ T cells, regulatory T cells, T helper 17 cells, and γδ T cells in modulating fracture healing. The current therapeutics targeting T cell immunity to enhance fracture healing have also been reviewed, aiming to provide insights from a translational standpoint. Overall, this work discusses recent advances and challenges in the interdisciplinary research field of T cell related osteoimmunology and its implications in fracture healing. The translational potential of this article: Delayed unions or non-unions of bone fractures remain a challenge in clinical practice. Developing a deep understanding of the roles of immune cells, including T cells, in fracture healing will facilitate the advancement of novel therapeutics of fracture nonunion. This review summarizes the current understanding of different T cell subsets involved in various phases of fracture healing, providing insights for targeting T cells as an alternative strategy to enhance bone regeneration.http://www.sciencedirect.com/science/article/pii/S2214031X24001621Bone formationFracture healingMesenchymal stem cellOsteoimmunologyT cell |
| spellingShingle | Haixing Wang Yashi Li Haoxin Li Xu Yan Zhaowei Jiang Lu Feng Wenhui Hu Yinuo Fan Sien Lin Gang Li T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration Journal of Orthopaedic Translation Bone formation Fracture healing Mesenchymal stem cell Osteoimmunology T cell |
| title | T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration |
| title_full | T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration |
| title_fullStr | T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration |
| title_full_unstemmed | T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration |
| title_short | T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration |
| title_sort | t cell related osteoimmunology in fracture healing potential targets for augmenting bone regeneration |
| topic | Bone formation Fracture healing Mesenchymal stem cell Osteoimmunology T cell |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X24001621 |
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