Modulation of miR-145 in a mouse model of multiple sclerosis: A promising approach to attenuate inflammation and degeneration

Modulation of miR-145 in a mouse model of multiple sclerosis: A promising approach to attenuate inflammation and degeneration

Multiple sclerosis (MS) is a progressive inflammatory disease of the central nervous system (CNS) marked by myelin loss, which impairs nerve function. Current therapies fail to halt disease progression or prevent myelin and axonal degeneration. In this study, we explored the impact of miR-145 loss i...

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Bibliographic Details
Main Authors: Monique Marylin Alves de Almeida, Samantha F. Kornfeld, Yves De Repentigny, Majd Al-Aarg, Ibrahim Ghani, Sarah E. Cummings, Emma R. Sutton, Rebecca Yaworski, Kelsea S. McKay, Sabrina Gagnon, Ariane Beauvais, Rashmi Kothary
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Myelin
Oligodendrocytes
Demyelination
Neuroinflammation
Neurodegeneration
microRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002153
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