Computational design of a glycosylated multi-epitope vaccine against HAsV-1 and HAsV-2 astrovirus for acute gastroenteritis

Computational design of a glycosylated multi-epitope vaccine against HAsV-1 and HAsV-2 astrovirus for acute gastroenteritis

Abstract Human astrovirus (HAsVs) is a significant viral agent responsible for acute gastroenteritis, primarily affecting children. Among HAsVs serotypes, HAsVs − 1 and HAsVs-2 are the most virulent serotypes, contributing to severe gastrointestinal infections, and having limited therapeutics. This...

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Bibliographic Details
Main Authors: Muhammad Naveed, Adeeba Ali, Tariq Aziz, Nouman Ali, Hafiz Muzzammel Rehman, Ayaz Ali Khan, Taqweem ul Haq, Rania Ali El Hadi Mohamed, Fahad Al-Asmari, Maher S. Alwethaynani, Fakhria A. Al-Joufi, Deema Fallatah
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
HAsVs
Glycan-sites
Vaccine candidate
Glycosylation
Immunoinformatic approach
Online Access:https://doi.org/10.1038/s41598-025-96989-2
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https://doi.org/10.1038/s41598-025-96989-2

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