Astrocytes and Developmental Plasticity in Fragile X
A growing body of research indicates a pivotal role for astrocytes at the developing synapse. In particular, astrocytes are dynamically involved in governing synapse structure, function, and plasticity. In the postnatal brain, their appearance at synapses coincides with periods of developmental plas...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/197491 |
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| author | Connie Cheng Mary Sourial Laurie C. Doering |
| author_facet | Connie Cheng Mary Sourial Laurie C. Doering |
| author_sort | Connie Cheng |
| collection | DOAJ |
| description | A growing body of research indicates a pivotal role for astrocytes at the developing synapse. In particular, astrocytes are dynamically involved in governing synapse structure, function, and plasticity. In the postnatal brain, their appearance at synapses coincides with periods of developmental plasticity when neural circuits are refined and established. Alterations in the partnership between astrocytes and neurons have now emerged as important mechanisms that underlie neuropathology. With overall synaptic function standing as a prominent link to the expression of the disease phenotype in a number of neurodevelopmental disorders and knowing that astrocytes influence synapse development and function, this paper highlights the current knowledge of astrocyte biology with a focus on their involvement in fragile X syndrome. |
| format | Article |
| id | doaj-art-83c51d486f60449e84e8fbaf1c2f034c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-83c51d486f60449e84e8fbaf1c2f034c2025-02-03T00:59:32ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/197491197491Astrocytes and Developmental Plasticity in Fragile XConnie Cheng0Mary Sourial1Laurie C. Doering2Department of Pathology and Molecular Medicine, McMaster University, HSC 1R1, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, HSC 1R1, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, HSC 1R1, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaA growing body of research indicates a pivotal role for astrocytes at the developing synapse. In particular, astrocytes are dynamically involved in governing synapse structure, function, and plasticity. In the postnatal brain, their appearance at synapses coincides with periods of developmental plasticity when neural circuits are refined and established. Alterations in the partnership between astrocytes and neurons have now emerged as important mechanisms that underlie neuropathology. With overall synaptic function standing as a prominent link to the expression of the disease phenotype in a number of neurodevelopmental disorders and knowing that astrocytes influence synapse development and function, this paper highlights the current knowledge of astrocyte biology with a focus on their involvement in fragile X syndrome.http://dx.doi.org/10.1155/2012/197491 |
| spellingShingle | Connie Cheng Mary Sourial Laurie C. Doering Astrocytes and Developmental Plasticity in Fragile X Neural Plasticity |
| title | Astrocytes and Developmental Plasticity in Fragile X |
| title_full | Astrocytes and Developmental Plasticity in Fragile X |
| title_fullStr | Astrocytes and Developmental Plasticity in Fragile X |
| title_full_unstemmed | Astrocytes and Developmental Plasticity in Fragile X |
| title_short | Astrocytes and Developmental Plasticity in Fragile X |
| title_sort | astrocytes and developmental plasticity in fragile x |
| url | http://dx.doi.org/10.1155/2012/197491 |
| work_keys_str_mv | AT conniecheng astrocytesanddevelopmentalplasticityinfragilex AT marysourial astrocytesanddevelopmentalplasticityinfragilex AT lauriecdoering astrocytesanddevelopmentalplasticityinfragilex |