CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cell-Like Cell Line

CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cell-Like Cell Line

Abstract Background Human spermatogonial stem cells (SSCs) exhibit a remarkable capacity for proliferation, crucial for sustaining spermatogenesis throughout life. While the Cullin-RING E3 ubiquitin ligase 2 (CRL2) complex is known to regulate various cellular functions, its precise role in human SS...

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Bibliographic Details
Main Authors: Bing Jiang, Kehan Wang, Haoyue Hu, Wenxin Gao, Cong Shen, Xia Chen, Xiaoyan Huang, Jun Yu, Yibo Wu, Bo Zheng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
LRRC41
DDX5
ELAVL1
Ubiquitination
Spermatogonial Stem Cells
Online Access:https://doi.org/10.1186/s12915-025-02363-z
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https://doi.org/10.1186/s12915-025-02363-z

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