The α-globin super-enhancer acts in an orientation-dependent manner

The α-globin super-enhancer acts in an orientation-dependent manner

Abstract Individual enhancers are defined as short genomic regulatory elements, bound by transcription factors, and able to activate cell-specific gene expression at a distance, in an orientation-independent manner. Within mammalian genomes, enhancer-like elements may be found individually or within...

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Main Authors: Mira T. Kassouf, Helena S. Francis, Matthew Gosden, Maria C. Suciu, Damien J. Downes, Caroline Harrold, Martin Larke, Marieke Oudelaar, Lucy Cornell, Joseph Blayney, Jelena Telenius, Barbara Xella, Yuki Shen, Nikolaos Sousos, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Andrew J. H. Smith, Christian Babbs, Jim R. Hughes, Douglas R. Higgs
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56380-1
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https://doi.org/10.1038/s41467-025-56380-1

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