Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression

Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression

Abstract Background Triple‐negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein‐coupled estrogen receptor (GPER), a novel estrogen receptor, is linked to increased malignancy in various c...

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Main Authors: Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yu‐An Qiu, Chunling Jiang, Bin Xu, Tenghua Yu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Medicine
Subjects:
CAFs
glutamine metabolism
GPER
TNBC
tumour progression
Online Access:https://doi.org/10.1002/ctm2.70131
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