A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence [version 2; peer review: 2 approved]

A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence [version 2; peer review: 2 approved]

Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons....

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Bibliographic Details
Main Authors: Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran
Format: Article
Language:English
Published: F1000 Research Ltd 2025-01-01
Series:F1000Research
Subjects:
UniProt ID P42858
HTT
Huntingtin
antibody characterization
antibody validation
western blot
eng
Online Access:https://f1000research.com/articles/13-922/v2
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https://f1000research.com/articles/13-922/v2

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