Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics.

Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics.

New sublineages of SARS-CoV-2 variants-of-concern (VOCs) continuously emerge with mutations in the spike glycoprotein. In most cases, the sublineage-defining mutations vary between the VOCs. It is unclear whether these differences reflect lineage-specific likelihoods for mutations at each spike posi...

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Main Authors: Roberth Anthony Rojas Chávez, Mohammad Fili, Changze Han, Syed A Rahman, Isaiah G L Bicar, Sullivan Gregory, Annika Helverson, Guiping Hu, Benjamin W Darbro, Jishnu Das, Grant D Brown, Hillel Haim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012215
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https://doi.org/10.1371/journal.pcbi.1012215

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