Acetylation of proximal cysteine-lysine pairs by alcohol metabolism

Acetylation of proximal cysteine-lysine pairs by alcohol metabolism

Alcohol consumption induces hepatocyte damage through complex processes involving oxidative stress and disrupted metabolism. These factors alter proteomic and epigenetic marks, including alcohol-induced protein acetylation, which is a key post-translational modification (PTM) that regulates hepatic...

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Bibliographic Details
Main Authors: Courtney D. McGinnis, Peter S. Harris, Brenton I.M. Graham, John O. Marentette, Cole R. Michel, Laura M. Saba, Richard Reisdorph, James R. Roede, Kristofer S. Fritz
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
Cysteine proteomics
Redox
Acetylation
Protein modeling
Alcohol-associated liver disease
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004403
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