Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study
ABSTRACT This study aimed to investigate the correlation of the increased volume index of epicardial adipose tissue (EAT) and left ventricular hypertrophy (LVH) in patients with Hypertension (HTN). A total of 209 HTN patients and 50 healthy controls, who underwent cardiovascular magnetic resonance (...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.70003 |
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| author | Runze Zhu Wenxian Wang Yan Gao Junchuan Liu Bowen Li Rongxue Shan Runjie Xue Xianshun Yuan Xi‐Ming Wang |
| author_facet | Runze Zhu Wenxian Wang Yan Gao Junchuan Liu Bowen Li Rongxue Shan Runjie Xue Xianshun Yuan Xi‐Ming Wang |
| author_sort | Runze Zhu |
| collection | DOAJ |
| description | ABSTRACT This study aimed to investigate the correlation of the increased volume index of epicardial adipose tissue (EAT) and left ventricular hypertrophy (LVH) in patients with Hypertension (HTN). A total of 209 HTN patients and 50 healthy controls, who underwent cardiovascular magnetic resonance (CMR) at two medical centers in China between June 2015 and October 2024, were enrolled for this study. Postprocessing and imaging analysis were conducted and EAT measurements were performed. Restricted cubic splines (RCS) were used to explore the potential relationship with LVH. Binary logistic regression models and mediation analyses were employed to evaluate the association between EAT volume and CMR parameters as well as LVH. Hypertensive patients with LVH exhibited larger indexed EAT volumes, more pronounced diffuse fibrosis, and reduced left ventricular strain compared to hypertensive patients without LVH (all p < 0.001), with results remaining stable after adjusting for confounding factors. The variables that were significant in the univariate regression were included in the multivariate logistic regression model, indicating that indexed EAT volume (p = 0.001), extracellular volume (ECV) (p = 0.012), and global longitudinal strain (GLS) (p = 0.024) were independently associated with LVH. These associations remained stable after adjusting for confounding factors. Mediation analysis further revealed that the relationship between increased EAT volume and LVH was mediated by ECV, native T1, GLS, global circumferential strain (GCS), and global radial strain (GRS) (p < 0.05). These findings imply that EAT is independently linked to LVH in hypertensive patients. The association between EAT and LVH in hypertensive patients may be mediated by myocardial fibrosis or dysfunction. |
| format | Article |
| id | doaj-art-82d716eaa30f4ebb9d7dc6ffba93bc00 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-82d716eaa30f4ebb9d7dc6ffba93bc002025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.70003Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort StudyRunze Zhu0Wenxian Wang1Yan Gao2Junchuan Liu3Bowen Li4Rongxue Shan5Runjie Xue6Xianshun Yuan7Xi‐Ming Wang8School of Radiology Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Interventional Medicine Qingdao Hiser Hospital‐Affiliated of Qingdao University Qingdao ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong ChinaABSTRACT This study aimed to investigate the correlation of the increased volume index of epicardial adipose tissue (EAT) and left ventricular hypertrophy (LVH) in patients with Hypertension (HTN). A total of 209 HTN patients and 50 healthy controls, who underwent cardiovascular magnetic resonance (CMR) at two medical centers in China between June 2015 and October 2024, were enrolled for this study. Postprocessing and imaging analysis were conducted and EAT measurements were performed. Restricted cubic splines (RCS) were used to explore the potential relationship with LVH. Binary logistic regression models and mediation analyses were employed to evaluate the association between EAT volume and CMR parameters as well as LVH. Hypertensive patients with LVH exhibited larger indexed EAT volumes, more pronounced diffuse fibrosis, and reduced left ventricular strain compared to hypertensive patients without LVH (all p < 0.001), with results remaining stable after adjusting for confounding factors. The variables that were significant in the univariate regression were included in the multivariate logistic regression model, indicating that indexed EAT volume (p = 0.001), extracellular volume (ECV) (p = 0.012), and global longitudinal strain (GLS) (p = 0.024) were independently associated with LVH. These associations remained stable after adjusting for confounding factors. Mediation analysis further revealed that the relationship between increased EAT volume and LVH was mediated by ECV, native T1, GLS, global circumferential strain (GCS), and global radial strain (GRS) (p < 0.05). These findings imply that EAT is independently linked to LVH in hypertensive patients. The association between EAT and LVH in hypertensive patients may be mediated by myocardial fibrosis or dysfunction.https://doi.org/10.1111/jch.70003epicardial adipose tissueextracellular volumehypertensiveleft ventricular hypertrophymyocardial fibrosis |
| spellingShingle | Runze Zhu Wenxian Wang Yan Gao Junchuan Liu Bowen Li Rongxue Shan Runjie Xue Xianshun Yuan Xi‐Ming Wang Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study The Journal of Clinical Hypertension epicardial adipose tissue extracellular volume hypertensive left ventricular hypertrophy myocardial fibrosis |
| title | Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study |
| title_full | Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study |
| title_fullStr | Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study |
| title_full_unstemmed | Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study |
| title_short | Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study |
| title_sort | epicardial adipose tissue and left ventricular hypertrophy in hypertensive patients with preserved ejection fraction a multicenter retrospective cohort study |
| topic | epicardial adipose tissue extracellular volume hypertensive left ventricular hypertrophy myocardial fibrosis |
| url | https://doi.org/10.1111/jch.70003 |
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