Evaluation of the therapeutic effects of the topical and systemic forms of Honokiol in 5-fluorouracil-induced oral mucositis model in rats

Evaluation of the therapeutic effects of the topical and systemic forms of Honokiol in 5-fluorouracil-induced oral mucositis model in rats

Abstract This study aimed to evaluate the effects of honokiol on 5-florourasil (5-FU) induced oral mucositis (OM) in rats. A total of 24 female Wistar Albino rats were injected with 5‑FU on day 1, 3 and 5. A superficial scratch was linearly created on the right buccal mucosa on days 3 and 5. The ani...

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Bibliographic Details
Main Authors: Ayse Ozcan Kucuk, Aydın Keskinruzgar, Zehra Bozdag
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Oral mucositis
5-florourasil
Honokiol
Healing
Oxidative stress
Histopathology score
Online Access:https://doi.org/10.1038/s41598-025-04628-7
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https://doi.org/10.1038/s41598-025-04628-7

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