Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report
ABSTRACT Acute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti‐TNF alpha therapy is known to be safe in pregnancy, however, data surrounding outcomes in ASUC is limited. In this report, we present the case of a pregnant pa...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70091 |
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| author | Saiumaeswar Yogakanthi Timothy Phan Emma Flanagan Linda Yang Chamara Basnayake Iniyaval Thevathasan Julien Schulberg |
| author_facet | Saiumaeswar Yogakanthi Timothy Phan Emma Flanagan Linda Yang Chamara Basnayake Iniyaval Thevathasan Julien Schulberg |
| author_sort | Saiumaeswar Yogakanthi |
| collection | DOAJ |
| description | ABSTRACT Acute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti‐TNF alpha therapy is known to be safe in pregnancy, however, data surrounding outcomes in ASUC is limited. In this report, we present the case of a pregnant patient of 10 weeks' gestation with ASUC successfully managed with intensified and accelerated infliximab therapy for a total dose of 35 mg/kg during a single admission. This case highlights the use of this therapeutic strategy, as a part of a multidisciplinary approach, to avoid the need for a high‐risk colectomy. |
| format | Article |
| id | doaj-art-8289f7846f84455c9692f8f2cd94c02d |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-8289f7846f84455c9692f8f2cd94c02d2025-01-28T09:24:32ZengWileyJGH Open2397-90702025-01-0191n/an/a10.1002/jgh3.70091Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case ReportSaiumaeswar Yogakanthi0Timothy Phan1Emma Flanagan2Linda Yang3Chamara Basnayake4Iniyaval Thevathasan5Julien Schulberg6Department of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaDepartment of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaDepartment of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaDepartment of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaDepartment of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaDepartment of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaDepartment of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria AustraliaABSTRACT Acute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti‐TNF alpha therapy is known to be safe in pregnancy, however, data surrounding outcomes in ASUC is limited. In this report, we present the case of a pregnant patient of 10 weeks' gestation with ASUC successfully managed with intensified and accelerated infliximab therapy for a total dose of 35 mg/kg during a single admission. This case highlights the use of this therapeutic strategy, as a part of a multidisciplinary approach, to avoid the need for a high‐risk colectomy.https://doi.org/10.1002/jgh3.70091clinical intestinal disordersgastroenterologyimmunologymicrobiology and inflammatory bowel diseases |
| spellingShingle | Saiumaeswar Yogakanthi Timothy Phan Emma Flanagan Linda Yang Chamara Basnayake Iniyaval Thevathasan Julien Schulberg Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report JGH Open clinical intestinal disorders gastroenterology immunology microbiology and inflammatory bowel diseases |
| title | Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report |
| title_full | Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report |
| title_fullStr | Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report |
| title_full_unstemmed | Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report |
| title_short | Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report |
| title_sort | intensified and accelerated rescue infliximab therapy for acute severe ulcerative colitis in pregnancy a case report |
| topic | clinical intestinal disorders gastroenterology immunology microbiology and inflammatory bowel diseases |
| url | https://doi.org/10.1002/jgh3.70091 |
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