Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)

Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)

ObjectiveThis study analyzed clinical characteristics, attack recovery and long-term disability accumulation in late-onset (LO ≥ 50 years at onset) versus early-onset (EO < 50 years) NMOSD.MethodsThis multicenter cohort study included demographic and clinical data from 446 NMOSD patients coll...

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Main Authors: Julian Reza Kretschmer, Daria Tkachenko, Tania Kümpfel, Joachim Havla, Daniel Engels, Friedemann Paul, Patrick Schindler, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Clarissa Zappe, Luisa Klotz, Lisa Revie, Eva Dawin, Makbule Senel, Hayrettin Tumani, Florian Then Bergh, Clemens Warnke, Markus Kraemer, Annette Walter, Antonios Bayas, Uwe K. Zettl, Ann-Sophie Lauenstein, Yavor Yalachkov, Thorleif Etgen, Matthias Kaste, Felix Luessi, Stefan Gingele, Sarah Passoke, Martin S. Weber, Jörn Peter Sieb, Axel Haarmann, Patrick Oschmann, Veit Rothhammer, Christian Geis, Markus C. Kowarik, Peter Kern, Matthias Grothe, Heike Stephanik, Klemens Angstwurm, Frank Hoffmann, Ulrike Wallwitz, Brigitte Wildemann, Sven Jarius, Jan-Patrick Stellmann, Thivya Pakeerathan, Carolin Schwake, Ilya Ayzenberg, Ingo Kleiter, Katinka Fischer, Orhan Aktas, Marius Ringelstein, Vivien Häußler, Corinna Trebst, Martin W. Hümmert
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
NMOSD = neuromyelitis optica spectrum disorder
aging
late onset
immunoscenecence
myelitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575613/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575613/full

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