A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH

A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH

Background & Aims: An imbalance between primary and secondary bile acids contributes to the development of metabolic dysfunction-associated steatohepatitis (MASH). The precise mechanisms underlying changes in the bile acid pool in MASH remain to be identified. As gut bacteria convert primary...

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Main Authors: Justine Gillard, Martin Roumain, Corinne Picalausa, Morgane M. Thibaut, Laure-Alix Clerbaux, Anne Tailleux, Bart Staels, Giulio G. Muccioli, Laure B. Bindels, Isabelle A. Leclercq
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:JHEP Reports
Subjects:
Bile acids
Enterohepatic cycle
7α-Dehydroxylation
7α-Rehydroxylation
Gut microbiota
Clostridium scindens
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924001526
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http://www.sciencedirect.com/science/article/pii/S2589555924001526

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