Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia

Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia

Abstract Background Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity of the strong hyperoxic hit p...

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Main Authors: Chiara Catozzi, Francesca Stretti, Enrica Scalera, Matteo Storti, Angelo Modena, Giorgio Aquila, Gino Villetti, Erica Ferrini, Andrea Grandi, Franco Fabio Stellari, Francesca Ravanetti, Luisa Ragionieri, Roberta Ciccimarra, Matteo Zoboli, Christina Brandenberger, Henri Schulte, Xabier Murgia, Maurizio Civelli, Francesca Ricci
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
Premature birth
Bronchopulmonary dysplasia
BPD
Preterm rabbits
micro-CT
Hyperoxia
Online Access:https://doi.org/10.1186/s12931-024-03053-0
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