Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects
Abstract Liposomes and lipid nanoparticles are common lipid-based drug delivery systems and play important roles in cancer treatment and vaccine manufacture. Although significant progress has been made with these lipid-based nanocarriers in recent years, efficient clinical translation of active targ...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Experimental Hematology & Oncology |
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| Online Access: | https://doi.org/10.1186/s40164-025-00602-1 |
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| _version_ | 1832571938934882304 |
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| author | Zhe Cheng Huichao Huang Meilong Yin Huaizheng Liu |
| author_facet | Zhe Cheng Huichao Huang Meilong Yin Huaizheng Liu |
| author_sort | Zhe Cheng |
| collection | DOAJ |
| description | Abstract Liposomes and lipid nanoparticles are common lipid-based drug delivery systems and play important roles in cancer treatment and vaccine manufacture. Although significant progress has been made with these lipid-based nanocarriers in recent years, efficient clinical translation of active targeted liposomal nanocarriers remains extremely challenging. In this review, we focus on targeted liposomes, stimuli-responsive strategy and combined therapy in cancer treatment. We also summarize advances of liposome and lipid nanoparticle applications in nucleic acid delivery and tumor vaccination. In addition, we discuss limitations and challenges in the clinical translation of these lipid nanomaterials and make recommendations for the future research in cancer therapy. Graphical Abstract |
| format | Article |
| id | doaj-art-822c510aa79c4b9685d95cb1d419f5fc |
| institution | Kabale University |
| issn | 2162-3619 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj-art-822c510aa79c4b9685d95cb1d419f5fc2025-02-02T12:12:03ZengBMCExperimental Hematology & Oncology2162-36192025-01-0114112110.1186/s40164-025-00602-1Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospectsZhe Cheng0Huichao Huang1Meilong Yin2Huaizheng Liu3Department of Emergency, The Third Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Emergency, The Third Xiangya Hospital, Central South UniversityDepartment of Emergency, The Third Xiangya Hospital, Central South UniversityAbstract Liposomes and lipid nanoparticles are common lipid-based drug delivery systems and play important roles in cancer treatment and vaccine manufacture. Although significant progress has been made with these lipid-based nanocarriers in recent years, efficient clinical translation of active targeted liposomal nanocarriers remains extremely challenging. In this review, we focus on targeted liposomes, stimuli-responsive strategy and combined therapy in cancer treatment. We also summarize advances of liposome and lipid nanoparticle applications in nucleic acid delivery and tumor vaccination. In addition, we discuss limitations and challenges in the clinical translation of these lipid nanomaterials and make recommendations for the future research in cancer therapy. Graphical Abstracthttps://doi.org/10.1186/s40164-025-00602-1LiposomeLipid nanoparticleCancer therapyTargeted deliveryTME, Tumor vaccination |
| spellingShingle | Zhe Cheng Huichao Huang Meilong Yin Huaizheng Liu Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects Experimental Hematology & Oncology Liposome Lipid nanoparticle Cancer therapy Targeted delivery TME, Tumor vaccination |
| title | Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects |
| title_full | Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects |
| title_fullStr | Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects |
| title_full_unstemmed | Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects |
| title_short | Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects |
| title_sort | applications of liposomes and lipid nanoparticles in cancer therapy current advances and prospects |
| topic | Liposome Lipid nanoparticle Cancer therapy Targeted delivery TME, Tumor vaccination |
| url | https://doi.org/10.1186/s40164-025-00602-1 |
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