The value of increasing sequencing depth for noninvasive prenatal screening for whole chromosomal aneuploidy

The value of increasing sequencing depth for noninvasive prenatal screening for whole chromosomal aneuploidy

Abstract To evaluate the value of increasing sequencing depths of non-invasive prenatal testing (NIPT) for fetal chromosomal aneuploidies based on the semiconductor sequencing platform. This study recruited a cohort of 59,800 singleton pregnancies from Guangdong Women and Children Hospital between J...

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Bibliographic Details
Main Authors: Dongmei Wang, Fangfang Guo, Yaping Hou, Haishan Peng, Tingting Hu, Jiexia Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Non-invasive prenatal testing (NIPT)
Sequencing depth
Fetal chromosome aneuploidy
Positive predictive value
Online Access:https://doi.org/10.1038/s41598-025-87218-x
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https://doi.org/10.1038/s41598-025-87218-x

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