The Impact of Astaxanthin Supplementation on the Lipid Profile
Astaxanthin (AST) is a carotenoid renowned for its strong antioxidant properties and its role as a pigment in various aquatic organisms. Initially isolated from lobster and subsequently characterized in detail, AST has garnered significant interest in recent years within the research, pharmaceutica...
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57675 |
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| author | Filip Arczewski Michalina Wójcikiewicz Witold Czyż Julia Kacperczyk Karol Dziedzic Marta Chuncia Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Wiktor Czaja Michał Krzciuk |
| author_facet | Filip Arczewski Michalina Wójcikiewicz Witold Czyż Julia Kacperczyk Karol Dziedzic Marta Chuncia Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Wiktor Czaja Michał Krzciuk |
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Astaxanthin (AST) is a carotenoid renowned for its strong antioxidant properties and its role as a pigment in various aquatic organisms. Initially isolated from lobster and subsequently characterized in detail, AST has garnered significant interest in recent years within the research, pharmaceutical, cosmetic, and supplement industries. This review aims to synthesize current literature on the impact of astaxanthin supplementation on lipid profiles, specifically focusing on low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. Evidence suggests that AST effectively prolongs the oxidation lag time of LDL, thereby mitigating the risk of atherosclerosis and cardiovascular diseases through its antioxidative mechanisms. The effects of AST on HDL-C levels are less consistent, with some studies reporting modest increases while others show no significant changes. Similarly, the influence of AST on triglyceride levels remains inconclusive, with studies presenting mixed outcomes ranging from significant reductions to negligible effects. AST is characterized by a high safety profile and favorable bioavailability, which is influenced by its source and isomeric composition. Despite these promising findings, many existing studies are limited by small sample sizes, heterogeneous participant groups, and varied dosing regimens, which impede the ability to draw definitive conclusions. Consequently, there is a need for larger, well-standardized clinical trials to accurately assess the efficacy and safety of astaxanthin as a therapeutic agent for lipid modulation and the prevention of metabolic disorders. Future research should focus on robust methodological designs and standardized supplementation protocols to clarify AST’s role in managing dyslipidemia and enhancing cardiovascular health.
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| format | Article |
| id | doaj-art-81cc720e794d4da2b53d4768ae9997ee |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
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| series | Quality in Sport |
| spelling | doaj-art-81cc720e794d4da2b53d4768ae9997ee2025-02-06T08:24:42ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.57675The Impact of Astaxanthin Supplementation on the Lipid ProfileFilip Arczewski0https://orcid.org/0009-0008-5179-7255Michalina Wójcikiewicz1https://orcid.org/0009-0003-3671-1410Witold Czyż2https://orcid.org/0009-0006-4442-9900Julia Kacperczyk3https://orcid.org/0009-0007-6354-301XKarol Dziedzic4https://orcid.org/0009-0007-8317-723XMarta Chuncia5https://orcid.org/0009-0000-0913-9752Maciej Wojszczyk6https://orcid.org/0009-0002-8668-8821Damian Zys7https://orcid.org/0009-0003-6578-6710Piotr Pasek8https://orcid.org/0009-0001-6218-9887Julia Ryniecka9https://orcid.org/0009-0000-5937-9498Wiktor Czaja10https://orcid.org/0009-0004-6221-2954Michał Krzciuk11https://orcid.org/0009-0004-2230-3456Medical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandPaniMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandCentral Teaching Hospital of the Medical University of LodzUniversity Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 ŁódźUniversity Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 Lodz, PolandCopernicus Memorial Hospital, ul. Pabianicka 62, 93-513 Lodz, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandPomeranian Medical University in Szczecin Rybacka Street 1, 70-204 Szczecin, Poland Pomorski Uniwersytet Medyczny w Szczecinie. ul. Rybacka 1, 70-204 Szczecin Astaxanthin (AST) is a carotenoid renowned for its strong antioxidant properties and its role as a pigment in various aquatic organisms. Initially isolated from lobster and subsequently characterized in detail, AST has garnered significant interest in recent years within the research, pharmaceutical, cosmetic, and supplement industries. This review aims to synthesize current literature on the impact of astaxanthin supplementation on lipid profiles, specifically focusing on low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. Evidence suggests that AST effectively prolongs the oxidation lag time of LDL, thereby mitigating the risk of atherosclerosis and cardiovascular diseases through its antioxidative mechanisms. The effects of AST on HDL-C levels are less consistent, with some studies reporting modest increases while others show no significant changes. Similarly, the influence of AST on triglyceride levels remains inconclusive, with studies presenting mixed outcomes ranging from significant reductions to negligible effects. AST is characterized by a high safety profile and favorable bioavailability, which is influenced by its source and isomeric composition. Despite these promising findings, many existing studies are limited by small sample sizes, heterogeneous participant groups, and varied dosing regimens, which impede the ability to draw definitive conclusions. Consequently, there is a need for larger, well-standardized clinical trials to accurately assess the efficacy and safety of astaxanthin as a therapeutic agent for lipid modulation and the prevention of metabolic disorders. Future research should focus on robust methodological designs and standardized supplementation protocols to clarify AST’s role in managing dyslipidemia and enhancing cardiovascular health. https://apcz.umk.pl/QS/article/view/57675astaxanthin lipid profileLDL cholesterolHDL cholesteroltriglyceridesantioxidants |
| spellingShingle | Filip Arczewski Michalina Wójcikiewicz Witold Czyż Julia Kacperczyk Karol Dziedzic Marta Chuncia Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Wiktor Czaja Michał Krzciuk The Impact of Astaxanthin Supplementation on the Lipid Profile Quality in Sport astaxanthin lipid profile LDL cholesterol HDL cholesterol triglycerides antioxidants |
| title | The Impact of Astaxanthin Supplementation on the Lipid Profile |
| title_full | The Impact of Astaxanthin Supplementation on the Lipid Profile |
| title_fullStr | The Impact of Astaxanthin Supplementation on the Lipid Profile |
| title_full_unstemmed | The Impact of Astaxanthin Supplementation on the Lipid Profile |
| title_short | The Impact of Astaxanthin Supplementation on the Lipid Profile |
| title_sort | impact of astaxanthin supplementation on the lipid profile |
| topic | astaxanthin lipid profile LDL cholesterol HDL cholesterol triglycerides antioxidants |
| url | https://apcz.umk.pl/QS/article/view/57675 |
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