Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice

Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice

Abstract Background Deficient DNA repair and excessive DNA damage contribute to neurodegenerative disease. However, the role of DNA damage and repair in spinal cord injury (SCI) is unclear. SCI, a debilitating disruption of the structural and biological network of the spinal cord, is characterized b...

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Bibliographic Details
Main Authors: Elle EM Scheijen, Naomi Veeningen, Sam Duwé, Anna Ivanova, Jana Van Broeckhoven, Sven Hendrix, David M Wilson
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Biomedical Science
Subjects:
Spinal cord injury
DNA damage
Oxidative stress
Gamma-H2AX
Neuronal death
DNA repair
Online Access:https://doi.org/10.1186/s12929-024-01104-8
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