Mechanism of nascent chain removal by the ribosome-associated quality control complex

Abstract Errors during translation can cause ribosome stalling, leaving incomplete nascent chains attached to large ribosomal subunits. Cells rely on the Ribosome-associated Quality Control (RQC) complex to recognize, process, and remove these aberrant proteins to maintain proteostasis. Despite its...

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Bibliographic Details
Main Authors: Wenyan Li, Talia Scheel, Peter S. Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61235-w
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