Crystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states.

Crystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states.

Glycyl tRNA synthetases (GlyRSs) are prospective drug targets for combating Mycobacterium tuberculosis (Mtb) and cancer in humans. These synthetases are of the α2-subtype, with the ortholog in humans being dual targeted to the cytosol and mitochondria. Whereas the human enzyme has been structurally...

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Main Authors: Michael K Fenwick, Amy E DeRocher, Justin K Craig, Elizabeth K Harmon, Steve Seibold, Lijun Liu, Kevin P Battaile, Lynn K Barrett, Wesley C Van Voorhis, Isabelle Q Phan, Bart L Staker, Sandhya Subramanian, Scott Lovell, Peter J Myler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326500
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https://doi.org/10.1371/journal.pone.0326500

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