Evaluating artesunate monotherapy and dihydroartemisinin-piperaquine as potential antimalarial options for prevaccination radical cures during future malaria vaccine field efficacy trials

Evaluating artesunate monotherapy and dihydroartemisinin-piperaquine as potential antimalarial options for prevaccination radical cures during future malaria vaccine field efficacy trials

Abstract Background In malaria vaccine clinical trials, immune responses after vaccination may be compromised due to immunosuppression caused by concurrent Plasmodium falciparum infection. This has a direct effect on the protective efficacy of the vaccine being evaluated. Therefore, parasite clearan...

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Main Authors: Alphonse Ouédraogo, Daouda Ouattara, San Maurice Ouattara, Amidou Diarra, Emilie S. Badoum, Alimatou Hema, Amidou Z. Ouédraogo, Denise Hien, Edith C. Bougouma, Issa Nébié, Valéry Bocquet, Michel Vaillant, Alfred B. Tiono, Sodiomon B. Sirima
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Malaria Journal
Subjects:
Malaria
Artesunate
Dihydroartemisinin-piperaquine
Radical cure
Infection
Incidence
Online Access:https://doi.org/10.1186/s12936-024-05198-1
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https://doi.org/10.1186/s12936-024-05198-1

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