An Incidental Finding of Gain of a Diminished Chromosome 12 Centromere in an Individual with Lymphocytosis: A Case Report and Clinical Implications in Cytogenetic Testing

An Incidental Finding of Gain of a Diminished Chromosome 12 Centromere in an Individual with Lymphocytosis: A Case Report and Clinical Implications in Cytogenetic Testing

<b>Background:</b> Fluorescence in situ hybridization (FISH) testing against chromosome 12 centromere (CEN12) is routinely included in the work-up of patients with suspected chronic lymphocytic leukemia (CLL) or monoclonal B-cell lymphocytosis (MBL). However, incidental findings can occu...

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Bibliographic Details
Main Authors: Changqing Xia, Jeffrey J. Cannatella, Scott C. Smith, Pamela A. Althof, Haley Koerselman, Thomas Hempel, Erin E. Jaworski, Lisa M. Winkler, Joanna R. Spaulding, Diane Pickering, Joseph D. Khoury, Zhenya Tang
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Diagnostics
Subjects:
centromere 12
centromere 16
rearrangement
fluorescence in situ hybridization (FISH)
chromosomal analysis
incidental finding
Online Access:https://www.mdpi.com/2075-4418/15/5/618
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