Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

Abstract Immune checkpoint blockade (ICB) has a limited effect on colorectal cancer, underlining the requirement of co‐targeting the complementary mechanisms. Here, we identified prostaglandin E2 (PGE2) receptor 4 (EP4) as the master regulator of immunosuppressive myeloid cells (IMCs), which are the...

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Main Authors: Weiqiang Lu, Weiwei Yu, Jiacheng He, Wenjuan Liu, Junjie Yang, Xianhua Lin, Yuanjin Zhang, Xin Wang, Wenhao Jiang, Jian Luo, Qiansen Zhang, Huaiyu Yang, Shihong Peng, Zhengfang Yi, Shancheng Ren, Jing Chen, Stefan Siwko, Ruth Nussinov, Feixiong Cheng, Hankun Zhang, Mingyao Liu
Format: Article
Language:English
Published: Springer Nature 2020-12-01
Series:EMBO Molecular Medicine
Subjects:
colorectal cancer
immunosuppressive myeloid cells
immunotherapy
prostaglandin E2 receptor 4
Online Access:https://doi.org/10.15252/emmm.202012798
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https://doi.org/10.15252/emmm.202012798

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