Enhanced differentiation of neural progenitor cells in Alzheimer’s disease into vulnerable immature neurons
Summary: Focusing on the early stages of Alzheimer’s disease (AD) holds great promise. However, the specific events in neural cells preceding AD onset remain elusive. To address this, we utilized human-induced pluripotent stem cells carrying APPswe mutation to explore the initial changes associated...
Saved in:
| Main Authors: | Joonho Cho, Simsung Bae, Juyeong Jeon, Janis Transfeld, Changyeob Lee, Alexi Nott, Fan Gao, Jinsoo Seo |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225007072 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons
by: Se-In Lee, et al.
Published: (2025-02-01) -
Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia
by: Isabella C. Galvão, et al.
Published: (2024-12-01) -
Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS
by: Barbara Szewczyk, et al.
Published: (2025-09-01) -
Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity
by: Lars Binkle-Ladisch, et al.
Published: (2024-12-01) -
Polyunsaturated fatty acids in lipid membranes regulate human neuronal function and amyloid-β production
by: Satoshi Morita, et al.
Published: (2025-06-01)