Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis

Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis

Abstract NOD-like receptor (NLR) family proteins are implicated in various cardiovascular diseases. However, the precise role of NLRC5, the largest member of this family, in myocardial infarction (MI) remains poorly understood. This study reveals that NLRC5 is upregulated in the hearts of both patie...

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Main Authors: Lingfeng Gu, Sibo Wang, Liuhua Zhou, Wenjing Wang, Yulin Bao, Ye He, Tongtong Yang, Jiateng Sun, Qiqi Jiang, Tiankai Shan, Chong Du, Zemu Wang, Hao Wang, Liping Xie, Aihua Gu, Yang Zhao, Yong Ji, Qiming Wang, Liansheng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07755-z
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https://doi.org/10.1038/s42003-025-07755-z

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