Functional conservation and divergence of arabidopsis VENOSA4 and human SAMHD1 in DNA repair

Functional conservation and divergence of arabidopsis VENOSA4 and human SAMHD1 in DNA repair

The human deoxyribonucleoside triphosphatase (dNTPase) Sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1) has a dNTPase-independent role in repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). Here, we show that VENOSA4 (VEN4), the probable Arabid...

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Bibliographic Details
Main Authors: Raquel Sarmiento-Mañús, Sara Fontcuberta-Cervera, Kensuke Kawade, Akira Oikawa, Hirokazu Tsukaya, Víctor Quesada, José Luis Micol, María Rosa Ponce
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
DNA repair
Arabidopsis
VENOSA4 gene
SAMHD1 ortholog
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024170508
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