Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study
Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) urbanized African teachers aged 25 to 60 yrs (mean 44.6 ± 9.6 yrs). Depress...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/426803 |
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| author | Mark Hamer Nancy Frasure-Smith François Lespérance Brian H. Harvey Nico T. Malan Leoné Malan |
| author_facet | Mark Hamer Nancy Frasure-Smith François Lespérance Brian H. Harvey Nico T. Malan Leoné Malan |
| author_sort | Mark Hamer |
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| description | Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) urbanized African teachers aged 25 to 60 yrs (mean 44.6 ± 9.6 yrs). Depressive symptoms were assessed using the self-administered 9-item Patient Health Questionnaire (PHQ-9). After adjusting for age, sex, and ethnicity, participants with severe depressive symptoms (PHQ-9 ≥ 15) had higher odds of hypertension defined from ambulatory BP and/or use of antihypertensive medication (odds ratio = 2.19, 95% CI, 1.00–4.90) in comparison to participants with no symptoms. Compared to Caucasians with no depressive symptoms, those with severe symptoms had blunted nocturnal systolic BP drop of 4.7 mmHg (95% CI, −0.5 to 10.0, P=0.07). In summary, depressive symptoms were associated with the circadian BP profile in black and Caucasian Africans. |
| format | Article |
| id | doaj-art-80d3cabe785041e89b21b98c007d8f9d |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-80d3cabe785041e89b21b98c007d8f9d2025-02-03T01:27:44ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/426803426803Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA StudyMark Hamer0Nancy Frasure-Smith1François Lespérance2Brian H. Harvey3Nico T. Malan4Leoné Malan5Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UKDepartment of Psychiatry and School of Nursing, McGill University CHUM Research Center, QC, CanadaDepartment of Psychiatry and School of Nursing, McGill University CHUM Research Center, QC, CanadaUnit for Drug Research and Development, Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom 2520, South AfricaHypertension in Africa Research Team (HART), School for Physiology, Nutrition, and Consumer Sciences, North-West University, Potchefstroom 2520, South AfricaHypertension in Africa Research Team (HART), School for Physiology, Nutrition, and Consumer Sciences, North-West University, Potchefstroom 2520, South AfricaDisturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) urbanized African teachers aged 25 to 60 yrs (mean 44.6 ± 9.6 yrs). Depressive symptoms were assessed using the self-administered 9-item Patient Health Questionnaire (PHQ-9). After adjusting for age, sex, and ethnicity, participants with severe depressive symptoms (PHQ-9 ≥ 15) had higher odds of hypertension defined from ambulatory BP and/or use of antihypertensive medication (odds ratio = 2.19, 95% CI, 1.00–4.90) in comparison to participants with no symptoms. Compared to Caucasians with no depressive symptoms, those with severe symptoms had blunted nocturnal systolic BP drop of 4.7 mmHg (95% CI, −0.5 to 10.0, P=0.07). In summary, depressive symptoms were associated with the circadian BP profile in black and Caucasian Africans.http://dx.doi.org/10.1155/2012/426803 |
| spellingShingle | Mark Hamer Nancy Frasure-Smith François Lespérance Brian H. Harvey Nico T. Malan Leoné Malan Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study International Journal of Hypertension |
| title | Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study |
| title_full | Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study |
| title_fullStr | Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study |
| title_full_unstemmed | Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study |
| title_short | Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study |
| title_sort | depressive symptoms and 24 hour ambulatory blood pressure in africans the sabpa study |
| url | http://dx.doi.org/10.1155/2012/426803 |
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