Drug reaction with eosinophilia and systemic symptoms syndrome
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a delayed form of severe cutaneous adverse reaction (SCAR) seen in association with certain drugs, especially anticonvulsants and allopurinol. Unlike other SCARs, DRESS is associated with significant systemic involvement such...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-01-01
|
| Series: | Indian Journal of Rheumatology |
| Subjects: | |
| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=59;epage=66;aulast=Shanoj |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832543022512865280 |
|---|---|
| author | K C Shanoj Sneha Joseph Padmanabha Shenoy |
| author_facet | K C Shanoj Sneha Joseph Padmanabha Shenoy |
| author_sort | K C Shanoj |
| collection | DOAJ |
| description | Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a delayed form of severe cutaneous adverse reaction (SCAR) seen in association with certain drugs, especially anticonvulsants and allopurinol. Unlike other SCARs, DRESS is associated with significant systemic involvement such as fever, lymphadenopathy, eosinophilia, renal failure, transaminitis, and myocarditis. Because of delayed onset of symptoms and a persistent course even after discontinuation of culprit drug, DRESS can mimic a variety of rheumatological disorders. Even though glucocorticoids are the mainstay of treatment, unlike other SCARs, DRESS is associated with a high incidence of viral reactivation, especially with members of the human Herpesviridae family. Early identification of the viral activation and prompt therapy is critical in the management of DRESS. |
| format | Article |
| id | doaj-art-80c1abd13cbe49c9ac09a03b04bbf2e4 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-80c1abd13cbe49c9ac09a03b04bbf2e42025-02-03T12:00:09ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012019-01-01145596610.4103/0973-3698.272151Drug reaction with eosinophilia and systemic symptoms syndromeK C ShanojSneha JosephPadmanabha ShenoyDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a delayed form of severe cutaneous adverse reaction (SCAR) seen in association with certain drugs, especially anticonvulsants and allopurinol. Unlike other SCARs, DRESS is associated with significant systemic involvement such as fever, lymphadenopathy, eosinophilia, renal failure, transaminitis, and myocarditis. Because of delayed onset of symptoms and a persistent course even after discontinuation of culprit drug, DRESS can mimic a variety of rheumatological disorders. Even though glucocorticoids are the mainstay of treatment, unlike other SCARs, DRESS is associated with a high incidence of viral reactivation, especially with members of the human Herpesviridae family. Early identification of the viral activation and prompt therapy is critical in the management of DRESS.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=59;epage=66;aulast=Shanojdrug inducedhypereosinophiliarash |
| spellingShingle | K C Shanoj Sneha Joseph Padmanabha Shenoy Drug reaction with eosinophilia and systemic symptoms syndrome Indian Journal of Rheumatology drug induced hypereosinophilia rash |
| title | Drug reaction with eosinophilia and systemic symptoms syndrome |
| title_full | Drug reaction with eosinophilia and systemic symptoms syndrome |
| title_fullStr | Drug reaction with eosinophilia and systemic symptoms syndrome |
| title_full_unstemmed | Drug reaction with eosinophilia and systemic symptoms syndrome |
| title_short | Drug reaction with eosinophilia and systemic symptoms syndrome |
| title_sort | drug reaction with eosinophilia and systemic symptoms syndrome |
| topic | drug induced hypereosinophilia rash |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=59;epage=66;aulast=Shanoj |
| work_keys_str_mv | AT kcshanoj drugreactionwitheosinophiliaandsystemicsymptomssyndrome AT snehajoseph drugreactionwitheosinophiliaandsystemicsymptomssyndrome AT padmanabhashenoy drugreactionwitheosinophiliaandsystemicsymptomssyndrome |