Direct detection from sputum for drug-resistant Mycobacterium tuberculosis using a CRISPR-Cas14a-based approach

Direct detection from sputum for drug-resistant Mycobacterium tuberculosis using a CRISPR-Cas14a-based approach

Abstract The increasing prevalence of multidrug-resistant tuberculosis (MDR-TB) highlights the urgent need for an efficient approach to identify Mycobacterium tuberculosis complex (MTBC) strains resistant to rifampicin (RIF) and isoniazid (INH). In response, we developed a CRISPR-Cas14a MTB RIF/INH...

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Bibliographic Details
Main Authors: Guohui Xiao, Houming Liu, Hui Xu, Hongyu Shi, Dongxin Liu, Min Ou, Peng Liu, Guoliang Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Microbiology
Subjects:
Tuberculosis
Drug-resistant
Rifampicin
Isoniazid
CRISPR-Cas14a
Online Access:https://doi.org/10.1186/s12866-025-03899-4
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https://doi.org/10.1186/s12866-025-03899-4

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