Genomic and immune profiling of breast cancer brain metastases

Abstract Background Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic alterations driving CNS recurrence,...

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Bibliographic Details
Main Authors: Amanda E. D. Van Swearingen, Marissa R. Lee, Layne W. Rogers, Alexander B. Sibley, Pixu Shi, Xiaodi Qin, Michael Goodin, Katelyn Seale, Kouros Owzar, Carey K. Anders
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
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Online Access:https://doi.org/10.1186/s40478-025-02001-3
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