Genomic and immune profiling of breast cancer brain metastases

Genomic and immune profiling of breast cancer brain metastases

Abstract Background Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic alterations driving CNS recurrence,...

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Main Authors: Amanda E. D. Van Swearingen, Marissa R. Lee, Layne W. Rogers, Alexander B. Sibley, Pixu Shi, Xiaodi Qin, Michael Goodin, Katelyn Seale, Kouros Owzar, Carey K. Anders
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Breast cancer
Brain metastasis
FFPE
Frozen
Intrinsic subtypes
Total RNA sequencing
Online Access:https://doi.org/10.1186/s40478-025-02001-3
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https://doi.org/10.1186/s40478-025-02001-3

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