COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS
The prevalence of allergic diseases was rapidly increasing in the 20th century. Currently, many people suffer from allergy in industrial countries. Therefore, analysis of allergenic properties of proteins is an urgent task. The following factors were formerly hypothesized to determine the allergenic...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2014-12-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/75 |
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| author | A. O. Bragin P. S. Demenkov E. S. Tiys R. Hofestädt V. A. Ivanisenko N. A. Kolchanov |
| author_facet | A. O. Bragin P. S. Demenkov E. S. Tiys R. Hofestädt V. A. Ivanisenko N. A. Kolchanov |
| author_sort | A. O. Bragin |
| collection | DOAJ |
| description | The prevalence of allergic diseases was rapidly increasing in the 20th century. Currently, many people suffer from allergy in industrial countries. Therefore, analysis of allergenic properties of proteins is an urgent task. The following factors were formerly hypothesized to determine the allergenicity of a protein: size, enzymatic properties, and similarity to human proteins. However, no analysis of the relationship between allergenicity of proteins and the habitat of the organisms producing them has been conducted hitherto. We predict allergenicity of proteins from proteomes of more than 500 species of microorganisms. It is shown that the number of allergenic proteins in the proteomes of microorganisms is significantly associated with their pathogenicity, habitat, temperature conditions of the habitat, and oxygen demand. |
| format | Article |
| id | doaj-art-8057ddb8311b4b77bd7e90e197a0c8c8 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-8057ddb8311b4b77bd7e90e197a0c8c82025-02-01T09:57:59ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592014-12-01164/178479059COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATSA. O. Bragin0P. S. Demenkov1E. S. Tiys2R. Hofestädt3V. A. Ivanisenko4N. A. Kolchanov5Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaBio-Medical Informatics Department, Bielefeld University, Bielefeld, GermanyInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, Russia National Research Centre «Kurchatov Institute», Moscow, RussiaThe prevalence of allergic diseases was rapidly increasing in the 20th century. Currently, many people suffer from allergy in industrial countries. Therefore, analysis of allergenic properties of proteins is an urgent task. The following factors were formerly hypothesized to determine the allergenicity of a protein: size, enzymatic properties, and similarity to human proteins. However, no analysis of the relationship between allergenicity of proteins and the habitat of the organisms producing them has been conducted hitherto. We predict allergenicity of proteins from proteomes of more than 500 species of microorganisms. It is shown that the number of allergenic proteins in the proteomes of microorganisms is significantly associated with their pathogenicity, habitat, temperature conditions of the habitat, and oxygen demand.https://vavilov.elpub.ru/jour/article/view/75protein allergenicity predictionallergenicity of microbial proteomeshabitat of microorganismsextremophiles |
| spellingShingle | A. O. Bragin P. S. Demenkov E. S. Tiys R. Hofestädt V. A. Ivanisenko N. A. Kolchanov COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS Вавиловский журнал генетики и селекции protein allergenicity prediction allergenicity of microbial proteomes habitat of microorganisms extremophiles |
| title | COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS |
| title_full | COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS |
| title_fullStr | COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS |
| title_full_unstemmed | COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS |
| title_short | COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS |
| title_sort | computerized analysis of the relationship between allergenicity of microorganisms and their habitats |
| topic | protein allergenicity prediction allergenicity of microbial proteomes habitat of microorganisms extremophiles |
| url | https://vavilov.elpub.ru/jour/article/view/75 |
| work_keys_str_mv | AT aobragin computerizedanalysisoftherelationshipbetweenallergenicityofmicroorganismsandtheirhabitats AT psdemenkov computerizedanalysisoftherelationshipbetweenallergenicityofmicroorganismsandtheirhabitats AT estiys computerizedanalysisoftherelationshipbetweenallergenicityofmicroorganismsandtheirhabitats AT rhofestadt computerizedanalysisoftherelationshipbetweenallergenicityofmicroorganismsandtheirhabitats AT vaivanisenko computerizedanalysisoftherelationshipbetweenallergenicityofmicroorganismsandtheirhabitats AT nakolchanov computerizedanalysisoftherelationshipbetweenallergenicityofmicroorganismsandtheirhabitats |