Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications
Diabetes is a systemic metabolic disorder primarily caused by insulin deficiency and insulin resistance, leading to chronic hyperglycemia. Prolonged diabetes can result in metabolic damage to multiple organs, including the heart, brain, liver, muscles, and adipose tissue, thereby causing various chr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/3248350 |
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| _version_ | 1850092929452867584 |
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| author | Jiajing Hong Shiqi Lu Guohui Shan Yaoran Yang Bailin Li Dongyu Yang |
| author_facet | Jiajing Hong Shiqi Lu Guohui Shan Yaoran Yang Bailin Li Dongyu Yang |
| author_sort | Jiajing Hong |
| collection | DOAJ |
| description | Diabetes is a systemic metabolic disorder primarily caused by insulin deficiency and insulin resistance, leading to chronic hyperglycemia. Prolonged diabetes can result in metabolic damage to multiple organs, including the heart, brain, liver, muscles, and adipose tissue, thereby causing various chronic fatal complications such as diabetic retinopathy, diabetic cardiomyopathy, and diabetic nephropathy. Single-cell RNA sequencing (scRNA-seq) has emerged as a valuable tool for investigating the cell diversity and pathogenesis of diabetes and identifying potential therapeutic targets in diabetes or diabetes complications. This review provides a comprehensive overview of recent applications of scRNA-seq in diabetes-related researches and highlights novel biomarkers and immunotherapy targets with cell-type information for diabetes and its associated complications. |
| format | Article |
| id | doaj-art-80310f63a4bf4e8aa42f4d6ddc6a19d0 |
| institution | DOAJ |
| issn | 2314-6753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-80310f63a4bf4e8aa42f4d6ddc6a19d02025-08-20T02:42:01ZengWileyJournal of Diabetes Research2314-67532025-01-01202510.1155/jdr/3248350Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes ComplicationsJiajing Hong0Shiqi Lu1Guohui Shan2Yaoran Yang3Bailin Li4Dongyu Yang5College of Acupuncture and MassageCollege of Acupuncture and MassageDepartment of EndocrinologyCollege of Acupuncture and MassageMedical Quality Monitoring CenterCenter of Traditional Chinese MedicineDiabetes is a systemic metabolic disorder primarily caused by insulin deficiency and insulin resistance, leading to chronic hyperglycemia. Prolonged diabetes can result in metabolic damage to multiple organs, including the heart, brain, liver, muscles, and adipose tissue, thereby causing various chronic fatal complications such as diabetic retinopathy, diabetic cardiomyopathy, and diabetic nephropathy. Single-cell RNA sequencing (scRNA-seq) has emerged as a valuable tool for investigating the cell diversity and pathogenesis of diabetes and identifying potential therapeutic targets in diabetes or diabetes complications. This review provides a comprehensive overview of recent applications of scRNA-seq in diabetes-related researches and highlights novel biomarkers and immunotherapy targets with cell-type information for diabetes and its associated complications.http://dx.doi.org/10.1155/jdr/3248350 |
| spellingShingle | Jiajing Hong Shiqi Lu Guohui Shan Yaoran Yang Bailin Li Dongyu Yang Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications Journal of Diabetes Research |
| title | Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications |
| title_full | Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications |
| title_fullStr | Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications |
| title_full_unstemmed | Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications |
| title_short | Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications |
| title_sort | application and progression of single cell rna sequencing in diabetes mellitus and diabetes complications |
| url | http://dx.doi.org/10.1155/jdr/3248350 |
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